Chemical substances used in agriculture (agrochemicals) have a significant impact on the quality of soil, surface and subsurface water. Their extensive and prolonged use over time causes negative effects on ecosystems.

Nanograss proposes the use of natural nano and micromaterials and food-grade polymers to develop smart agrochemicals with a lower environmental impact (and associated economical advantages). Nanograss is a technological platform, applicable to a broad spectrum of pesticides for which controlling leaching, volatilization and premature degradation is a priority.

Patent Status

PENDING

Priority Number

2019IT-TO06852

Priority Date

15/05/2019

License

INTERNATIONAL

Market

The global Agrochemical market was 223.7 billion USD in 2018 and is expected to be 308.4 billion USD by the end of 2025, with an annual growth rate of 4.69%. In EU, forecasts indicate an increase of the market size from 27.21 billion USD in 2016 to 39.15 billion USD by 2022 and even more in year 2025.
The global market size for the sale of slow and controlled release pesticides was USD 1.7 billion in 2016 and is anticipated to grow at an annual rate of 7.3% up to 2025. The limited arable land area and rising demand for food by growing population are expected to drive the segment growth in the next years.

Problem

The extensive use of pesticides is a common, and often unavoidable, practice in agriculture, but presents numerous drawbacks related to their toxicity and mobility in the environment.
The main environmental problems associated with agrochemicals depend of the characteristics of the specific compound. Ultimately, the most critical products are those characterized by a significant dispersion in the environment (both during the application to crop and later on, when irrigation and rain events disperse them in surface water and groundwater), by a significant toxicity toward humans and other non-target organisms (crops, insects, etc.) and by a high persistency (because scarcely biodegradable and/or photodegradable). On the other hand, some common pesticides, although extremely effective and eventually less toxic that broadly used competitors, have a limited use, since they are too volatile or soluble, and consequently a large quantity of product applied in the field is lost in the environment.
The environmental issues associated to agrochemical products have also obvious economic drawbacks, including the recall from the market, the adoption of limitations on its uses, and the need to develop alternative formulations.

Current Technology Limits

The environmental issues associated with the current pesticide formulations, along with more stringent national and international regulations (in particular in Europe) have led to the ban of numerous “traditional” pesticides, with carcinogenic and/or strongly toxic effects. The recent European Green Deal represents a strong drive in this sense. This context pushes the agrochemical companies to develop more environmental friendly alternatives based on less toxic active substances (which often have problems in practical uses due to fast degradation and/or difficult handling) or to find new formulations for existing toxic pesticides that make them less mobile in the environment and less bioavailable.
Nevertheless, the formulations based on more traditional approaches /(e.g. use of co-formulants aimed at increase/reduce the solubility of a compound, preservatives aimed at slowing down the degradation of natural compounds, etc.) are often characterized by technical or authorizative issues. As an alternative, nanopesticides (based on the use of nanomaterials, like Nanograss) have been proposed, but the solutions already on the international market are in most cases based on synthetic, not biodegradable materials, which are themselves potentially toxic.

Killer Application

The main applications of this technology are:
– The development of pesticides with lower environmental impact, using common active ingredients and combining them with sustainable biodegradable materials that make them less mobile in the environment;
– The possibility to extend the approach to other typologies of active ingredients/composites used in agriculture, such as fertilizers/soil improvers/bio-active ingredients that need a specific protection and improvement to promote their full-scale application
Nanograss is a technological platform, applicable and adaptable to numerous different active principles and to solve different compound-specific problems.

Our Technology and Solutions

The Nanograss approach allows to synthesize nano-agrochemicals characterized by a low environmental impact, constituted by nanoparticles (NPs), usually referred to as nanocarriers, containing an active ingredient (AI) – that is, the pesticide itself – and dispersed in a colloidal suspension.
Nanograss takes advantage of the affinity of most pesticide molecules with natural substrates: the pesticide is bounded to the carrier and eventually protected by a shell of biodegradable polymer that tunes its release over time.
Nanograss has been successfully applied to reduce volatility and solubility of a well-known herbicide. Nanograss formulation allows to convey the pesticide where it is most needed and reduce the amount of AI that can leach in soil and reach groundwater in presence of a rainfall or irrigation. Nanograss formulation can be applied in greenhouse or in field using the conventional pesticide spray and nebulization technology available, due to its micro/nano particles size.
The Nanograss approach has been demonstrated for a first pesticide, and the development for a second compound is ongoing. The application to a new compound requires going through several steps (compound-specific selection of a carrier and polymer, synthesis procedure, preliminary testing of efficacy and environmental mobility) and consequently it is a customized process, expected to be carried out in collaboration with an industrial customer (i.e. a pesticide company).

Advantages

The Nanograss platform permits the development of pesticide nanoformulation with the following advantages:
– the reduction of volatilization and lisciviation. Reduced leaching may mean, depending on the compound, that a pesticide can be authorized for use in a broader spectrum of conditions (e.g. mobile pesticides may not be authorized on very permeable soils), can be applied at lower doses (since less compound is lost without targeting the pests) or have a longer permanence in soil (thus avoiding, for some compounds, frequent application).
– the improvement of the delivery of poorly soluble AIs, or conversely the control and retardation of soluble AIs release;
– the use of greener pesticides of natural origin, less toxic (at least to humans) than the synthetic corresponding products, whose industrial application is often limited due to their inherent fast degradation.

Roadmap

– For at least one pesticide compound it is still to be demonstrated the efficacy and scalability to field scale and the long-term stability of the product.
– The possibility of developing efficient nano-formulations with other active ingredients different from that used up to now is being proved.
The development is expected to be a custom process, carried out in collaboration with a pesticide company interested in bringing the new nanoformulation to the market.

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